Adrafinil versus Modafinil
Adrafinil has gained a lot of popularity in recent years because of its similarity to Modafinil and its accessibility. Adrafinil is actually a food supplement that can be bought without a prescription. The chemical structure of Adrafinil is just like Modafinil with an addition of OH (hydroxyl group) to the amide nitrogen, forming it to hydroxylamine. Modafinil is in comparison a lot more powerful than Adrafinil. Adrafinil, modafinil
Adrafinil is a prodrug for Modafinil. This means that it is converted to Modafinil in the body, this is the biologically active agent. The only part of Adrafinil is converted to Modafinil, the remainder being metabolized to inactive Modafinilic acid.
Modafinilic acid is also a metabolite of Modafinil itself. It is unclear what the percentage of Adrafinil is that is converted to Modafinil. This percentage would be a good indication of Adrafin’s potential compared to Modafinil.
We prefer Modafinil because Adrafinil produces modafinil in the body in an inefficient and indirect way, and you need a higher dose to achieve the same effect. Adrafinil, modafinil
Adrafinil and liver toxicity
Rumor has it that Adrafinil can be hepatotoxic (damaging the liver). Since converting Adrafinil to Modafinil requires liver enzymes, it could damage the liver.
It remains unclear what P450 cytochrome (liver enzymes) of Adrafinil converts to Modafinilzuur and Modafinil. But there is no clear evidence that Adrafinil damages the liver.
Where do the rumors about Adrafinil and liver damage come from?
An Adrafinil user reported that he had elevated transaminases in a blood test. Transaminases are liver enzymes that are sometimes elevated due to liver toxicity. But there are many more reasons why the transaminases can be increased. Adrafinil, modafinil
This single case is certainly not enough evidence that Adrafinil is worse for your liver than Modafinil. Modafinil itself is hardly associated with transaminase elevation (<1%). Since Adrafinil is a prodrug for Modafinil, it is difficult to distinguish the effects of Adrafinil versus Modafinil on liver functions.
Adrafinil versus Modafinil: General Comparison
Prodrug. Adrafinil is a precursor that is converted to Modafinil in the body; therefore the effects of both agents are almost the same.
Category. Adrafinil is unregulated in the EU and can, therefore, be sold as a dietary supplement, Modafinil is categorized in the Medicines Act, requiring a prescription. Adrafinil, modafinil
Legal status. Adrafinil is offered online and sold as nootropic and nutraceutical, while Modafinil can only be purchased online.
Power. Adrafinil is less powerful than Modafinil; therefore, a higher dosage is required to achieve the same effect.
Dosage. A typical dose of Adrafinil is 300-600mg versus 200mg for Modafinil
Length of time. The duration of Adrafinil is about 5 hours, but this effect remains longer with Modafinil because it is an active metabolite and takes about 14 hours. Adrafinil, modafinil
Physical Characteristics. Adrafinil is a whitish powder with an orange tint, where Modafinil is white or off-white.
Effects of Adrafinil and Modafinil
Adrafinil is metabolized to Modafinil in vivo (in the body). Technically, Adrafinil and Modafinil have the same pharmacological effects. The effects include increased irritability and vigilance, reduced fatigue and possibly improved functions in some individuals.
But because Modafinil is the active metabolite of Adrafinil and not all Adrafinil in the body is converted to Modafinil (some are converted to the inactive metabolite Modafinilic acid), Adrafinil is less potent than Modafinil. Adrafinil, modafinil
When comparing Adrafinil with Modafinil, it is important to remember that twice as many Adrafinil (in terms of mg) is needed to achieve the same effects as Modafinil.
Adrafinil and Modalert (Modafinil) differ in terms of legal status.
Modafinil is a prescribed medication in the Netherlands. Most of the people of the people here let Modafinil come from overseas; rarely packages are seized at customs, but very rarely (or never) legal actions have been taken. Adrafinil, modafinil
Adrafinil, despite being a prodrug of Modafinil, is unregulated in UK and can be sold as a dietary supplement. This makes Adrafinil cheaper and easier to obtain.